Pregabalin: important advice about pregnancy

Last Updated: Monday, 12 October 2026

Pregabalin, also known as Lyrica, treats nerve pain, epilepsy and anxiety.

The MHRA, the UK medicines regulator, has warned that taking pregabalin during pregnancy may slightly increase the risk of serious birth defects, particularly during the first 3 months.

This does not mean every baby exposed to pregabalin will be affected. Your clinician can help you understand the benefits and risks of treatment.

What should you do?

• Use effective contraception while taking pregabalin if you could become pregnant. Ask your clinician or pharmacist which method is suitable.
• Speak to your prescriber before trying for a baby. They can review your treatment and discuss alternatives.
• Contact your prescriber promptly if you become pregnant or think you may be pregnant.
• Do not stop pregabalin suddenly or change your dose yourself. Your clinician will advise how to make any changes safely.

Pregabalin should only be used during pregnancy when clearly necessary, after discussing the benefits, risks and alternatives with your clinician.

Want to discuss your medicine?

Contact your GP practice to book a medication review with a clinician. Tell the practice if you are pregnant or planning a pregnancy so they can arrange timely advice.

You can find more information here: Pregabalin and risks in pregnancy - GOV.UK

Read the full MHRA alert.