Mycophenolate: important pregnancy-prevention advice

Last Updated: Monday, 12 October 2026

Mycophenolate mofetil and mycophenolic acid reduce the activity of your immune system. They help prevent rejection after an organ transplant or manage certain autoimmune conditions.

The MHRA, the UK medicines regulator, warns that taking mycophenolate during pregnancy can cause miscarriage and serious birth defects.

Women who could become pregnant

• Use at least one reliable method of contraception before starting treatment, throughout treatment and for 6 weeks after stopping. Two methods are preferred.
• Ask your clinician which contraception is suitable for you.
• You need pregnancy testing before starting treatment and may need further tests during treatment.
• Speak to your specialist before trying for a baby. Your treatment may need changing.

Men taking mycophenolate

As a precaution, you or your female partner should use reliable contraception during treatment and for at least 90 days after stopping.

Current evidence does not show an increased risk to babies when the father takes mycophenolate, but a risk cannot be completely ruled out. Speak to your specialist before planning a baby.

If pregnancy happens or is suspected

Contact your specialist immediately if you think you or your partner may be pregnant, or contraception has failed. Do not wait for a routine review.

Do not stop mycophenolate without medical advice.

Want to discuss your medicine?

Contact your GP practice to book a medication review with a clinician if you have questions about treatment, contraception or planning a pregnancy.

Read the updated MHRA advice.