Hydrochlorothiazide: important advice about skin protection

Last Updated: Monday, 12 October 2026

Hydrochlorothiazide is a “water tablet” used to treat high blood pressure and fluid build-up. It may be combined with another medicine in the same tablet.

The MHRA, the UK medicines regulator, has warned that hydrochlorothiazide is linked to an increased risk of some skin cancers, including cancers affecting the lips. The risk increases with the total amount taken over time, particularly with long-term use.

What should you do?

• Check your skin and lips regularly. Contact your GP if you notice a new lump, sore or patch, or a change to an existing mark or mole.
• Protect yourself from sunlight. Use sunscreen, cover exposed skin and seek shade.
• Avoid sunbeds.
• Tell your clinician if you have previously had skin cancer. They may recommend a different medicine.
• Do not stop hydrochlorothiazide or change your dose without medical advice.

Want to discuss your medicine?

Contact your GP practice to book a medication review with a clinician if you have concerns or want to discuss alternatives.

If you notice a suspicious skin change, ask for an appointment to have it examined rather than waiting for a routine medication review.

Read the full MHRA alert.